Research

Focused Ultrasound Therapy (Histotripsy and Beyond)

We develop non-invasive therapy to treat diseased tissue without radiation, heat, or surgical resection using focused ultrasound. We work on all aspects of ultrasound therapy, including image guidance, treatment planning, treatment optimization, real-time feedback and monitoring, post-treatment evaluation, and combined treatment with other therapeutics. By improving the efficacy, efficiency, and precision, we aim to provide safer, more effective, and more personalized therapy for more patients.

Real-time Volumetric Imaging

Conventional ultrasound imaging is primarily performed in two-dimensional cross-sectional planes, whereas biological tissues and pathologies are inherently three-dimensional. We develop real-time volumetric ultrasound imaging that provides high-resolution visualization of anatomical, functional, and physiological information in 3D. Such dynamic capability can not only enhance diagnostic accuracy but also improve clinical decision-making during image-guided interventions and therapies.

Ultrasound Instrumentation

Hardware innovation is a critical driver of advances in ultrasound. We develop ultrasound transducers, electronics, and scalable systems ranging from preclinical research systems to compact point-of-care devices, with an ultimate goal to expand the clinical reach of ultrasound.

Computational Methods in Biomedical Ultrasound

We are interested in computational methods for ultrasound, including acoustic simulation, parallel computing for real-time algorithms, and AI-assisted image formation and analysis. These approaches enable faster, more accurate, and more intelligent ultrasound technologies for imaging and therapy in patient care.

From Preclinical Studies to Clinical Translation

We validate the new technologies developed in the lab through preclinical studies and close collaboration with clinical partners. By aligning technology development with unmet clinical needs, we aim to accelerate translation and deliver solutions that improve patient care and clinical outcomes.

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